The second week of the 2019 Six Nations is already upon us and Scotland will be looking to push on after moving to the top of the table last week after their win over Italy.

Ireland face a tough trip this week when they head to Murrayfield for their second match of the competition against the Scots.

Coach Joe Schmidt makes five changes, with Chris Farrell, Rob Kearney, Quinn Roux, Sean O’Brien and Jack Conan all come into the starting XV.

Holders Ireland lost their first game against England 32-20 – a bruising encounter – and Scotland will be trying to take advantage. Blair Kinghorn has been left out despite scoring a hat-trick against Italy in the 33-20 win.

Ireland are 13/25 favourites while Scotland are 9/4 to record a second win.

The second game on Saturday sees Italy host Wales in Rome, with Warren Gatland’s side expected to cruise to victory.

Gatland has made 10 changes to his team after beating France in week one. Jonathan Davies will captain the side for the first time, with Alun Wyn Jones among the replacements. Jonah Holmes, Thomas Young, Aaron Wainwright and Aled Davies all earn first Six Nations starts.

Italy, who are as big as 11/1 to win this week, have made two changes, with Wasps’ Michele Campagnaro switching from wing to centre. Edoardo Padovani comes in on the wing while Nicola Quaglio replaces Andrea Lovotti at prop.

Sunday’s only game sees England welcome France to Twickenham a week after their brave victory in Ireland and Eddie Jones has recalled Bath wing Joe Cokanasiga to the 25-man squad.

Dan Cole comes in for Harry Williams and Ben Moon replaces Ellis Genge. Lock Joe Launchbury is set to feature in the 23-man squad, with Maro Itoje out with a knee problem.

England remain overwhelming favourites while France are 6/1 outsiders for the trip across the Channel.